Methylamine → HCID 23284781, compound

Participants

Reaction Steps

8-Chloro-6,7-difluoro-1-[3,5-difluoro-6-(2-hydroxyethylamino)pyridin-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (250 mg) and an aqueous solution (about 40%; 3 g) of methylamine were added to isopropyl alcohol (4 ml), and the mixture was stirred at room temperature for 15 hours. The reaction mixture was concentrated under reduced pressure. A process of adding ethanol (2 ml) to the residue and then concentrating the mixture under reduced pressure was conducted twice repeatedly. Ethanol (2 ml) was added to the resultant residue, and deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (175 mg) as a pale brown powder.

Provenance & Evidence