Methylamine → HCID 23284754, compound

Participants

Reaction Steps

1-(5-Amino-2,4-difluorophenyl)-6,7-difluoro-8-methylthio-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (50 mg) was added to pyridine (100 mg). A 40% aqueous solution (120 mg) of methylamine was added, and the resultant mixture was stirred overnight at room temperature and for additional 2 days at 50° C. After the reaction mixture was allowed to cool, the solvent was distilled off under reduced pressure. Ethanol (1 ml) was added to the residue, and solids deposited were collected by filtration to obtain the title compound (25 mg) as a pale brown powder.

Provenance & Evidence