Methylamine → HCID 23284786, compound

Participants

Reaction Conditions

Reaction Steps

Dimethyl sulfoxide (100 mg) and a 40% aqueous solution (50 mg) of methylamine were added to 1-(5-amino-2,4-difluorophenyl)-7-fluoro-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (30 mg), and the mixture was heated and stirred at 40° C. for 3 days. The solvent and the like were distilled off under reduced pressure, and ethanol (0.5 ml) was added to the residue. The mixture was left to stand for 3 days, and solids deposited were collected by filtration and washed with (ethanol and diethyl ether to obtain the title compound (11 mg) as a pale gray powder.

Provenance & Evidence