Dimethylformamide → HCID 23284755, compound

Participants

Reaction Conditions

Reaction Steps

N,N-Dimethylformamide (4 ml), potassium carbonate (0.6 g) and methyl iodide (0.6 g) were added to ethyl 1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-6,7-difluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (1.0 g), and the mixture was stirred overnight at 60° C. Ethyl acetate and water were added to the reaction mixture to collect an organic layer. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off. Ethanol was added to the residue, and solids deposited were collected to obtain the title compound (410 mg) as a colorless powder.

Provenance & Evidence