Methylamine → HCID 23284693, compound

Participants

Reaction Conditions

Reaction Steps

Pyridine (300 mg) and a 40% aqueous solution (150 mg) of methylamine were added to 1(5-amino-2,4-difluorophenyl)-6,7-difluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg), and the mixture was stirred overnight at 40° C. The solvent and the like were distilled off, and diethyl ether was added to the residue. A supernatant liquid was removed, and ethanol was added to the resultant residue. Solids deposited were collected by filtration to obtain the title compound (34 mg) as a yellow powder.

Provenance & Evidence