Pyridine → HCID 23284812, compound

Participants

Reaction Conditions

Reaction Steps

Pyridine (500 mg) and a 40% aqueous solution (300 mg) of methylamine were added to 1-(5-amino-2,4-difluorophenyl)-7-fluoro-8-methyl-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (220 mg), and the mixture was stirred for 3 hours at 40° C. and for 2 days at room temperature. Diethyl ether was added to the reaction mixture, followed by stirring. A supernatant liquid was removed, and acetic acid (3 drops) was added to the residue, followed by stirring. Solids deposited were recrystallized from ethanol and N,N-dimethylformamide to obtain the title compound (190 mg) as a reddish brown powder.

Provenance & Evidence