Ammonia → HCID 23284700, compound

Participants

Reaction Conditions

Reaction Steps

Pyridine (1.0 ml) and 28% aqueous ammonia (100 mg) were added to 1-(5-amino-2,4-difluorophenyl)-7-fluoro-8-methyl-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg), and the mixture was stirred at 50° C. for 2 days. Additional 28% aqueous ammonia (0.5 ml) was added, and the mixture was further stirred overnight at 50° C. Diethyl ether was added to the reaction mixture, followed by stirring. A supernatant liquid was removed, and ethanol was added to the residue. Solids deposited were collected by filtration and washed with ethanol to obtain the title compound (59 mg) as a yellow powder.

Provenance & Evidence