Pyridine → HCID 23284796, compound

Participants

Reaction Conditions

Reaction Steps

Pyridine (300 mg) and a 70% aqueous solution (150 mg) of ethylamine were added to 1-(5-amino-2,4-difluorophenyl)-7-fluoro-8-methyl-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (110 mg), and the mixture was stirred at 50° C. for 3 hours. Diethyl ether was added to the reaction mixture, followed by stirring. A supernatant liquid was removed, and solids deposited were recrystallized from N,N-dimethylformamide. The solids were collected by filtration and washed with ethanol to obtain the title compound (75 mg) as a reddish brown powder.

Provenance & Evidence