HCID 23284678, compound → HCID 23284677, compound

Participants

Reaction Steps

Palladium hydroxide-carbon (180 mg) was added to a solution of ethyl 7-azido-1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-8-chloro-6-fluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (1.75 g) in methanol (9 ml), and the mixture was stirred at room temperature for 2.5 hours in a hydrogen atmosphere. The catalyst was removed by filtration through a membrane filter, and the solvent in the filtrate was distilled off under reduced pressure. The residue was subjected to column chromatography on silica gel to conduct elution with chloroform, thereby obtaining the title compound (1.75 g) as a brown oil.

Provenance & Evidence