Acetonitrile → HCID 53978682, compound

Participants

Reaction Conditions

Reaction Steps

N-Methylenediamine (17 mg) and triethylamine (35 mg) were added to acetonitrile (5 ml), to which 1-(5-amino-2,4-difluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) was added with heating and stirring at 60° C. The resultant mixture was heated under reflux for 2 hours as it was. After the reaction mixture was allowed to cool, solids deposited were collected by filtration and washed with ethanol and diethyl ether to obtain the title compound (40 mg) as a pale brown powder.

Provenance & Evidence