Pyridine → HCID 23284665, compound

Participants

Reaction Conditions

Reaction Steps

5-Amino-1-(5-amino-2,4-difluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) and a methylamine solution (82 mg) were added to pyridine (1 ml), and the mixture was heated and stirred at 30° C. for 4 days. After the reaction mixture was allowed to cool, it was concentrated under reduced pressure. Ethanol was added to the residue, and solids were collected by filtration and washed with diethyl ether to obtain the title compound (63 mg) as a brown powder.

Provenance & Evidence