Hydrochloric Acid → HCID 23284716, compound

Participants

Reaction Steps

Ethyl 1-[5-(tert-butoxycarbonylamino)-2,4-difluorophenyl]-6,7-difluoro-8-isopropyloxy-4-oxo-1,4-dihydroquinoline-3-carboxylate (530 mg) were added to a mixed liquid of 4N hydrochloric acid (2 ml) and acetic acid (2 ml), and the mixture was stirred and heated under reflux for 50 minutes. The reaction mixture was concentrated under reduced pressure. Deposits were dispersed in ethanol, collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (285 mg) as a pale brown powder.

Provenance & Evidence