Hydrogen Bromide → HCID 23284813, compound

Participants

Reaction Steps

48% hydrobromic acid (3 ml) and acetic acid (2 ml) were added to ethyl 7-amino-1-(2,4-difluoro-5-methoxyphenyl)-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (420 mg), and the mixture was stirred for 2 days while heating under reflux. After the reaction mixture was allowed to cool, solids deposited were collected by filtration. The solids were washed with water, ethanol and diethyl ether in that order and dried to obtain the title compound (108 mg) as a pale brown powder.

Provenance & Evidence