Potassium Nitrate → HCID 23284719, compound

HRID 369325Notes

Reaction equation

HRID 369325 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:22])=[C:15]([N+:19]([O-:21])=[O:20])[C:16]=3[CH3:18])[C:11](=[O:23])[C:10]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:9]2)=[C:4]([CH3:29])[CH:3]=1.[N+:30]([O-])([O-:32])=[O:31].[K+]>S(=O)(=O)(O)O>[F:1][C:2]1[C:7]([N+:30]([O-:32])=[O:31])=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:22])=[C:15]([N+:19]([O-:21])=[O:20])[C:16]=3[CH3:18])[C:11](=[O:23])[C:10]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:9]2)=[C:4]([CH3:29])[CH:3]=1

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 23284684HCID 23284684, compound

Product 1

HCID 23284719HCID 23284719, compoundYield 89.9%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

Ethyl 1-(4-fluoro-2-methylphenyl)-6-fluoro-8-methyl-7-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1.1 g) was added to concentrated sulfuric acid (10 ml), and potassium nitrate (330 mg) was added to the mixture under ice cooling. The resultant mixture was stirred at room temperature for 4 days. The reaction mixture was poured into ice water and extracted with chloroform. A chloroform layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off to obtain the title compound (1.1 g) as a pale yellow amorphous substance.

Workup

  1. additionwas added to the mixture under ice cooling
  2. extractionextracted with chloroform
  3. dry with materialA chloroform layer was dried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-530f1049adc94f5e894da2bf7485d109
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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