Citric Acid → HCID 23284721, compound

Participants

Reaction Steps

Ethyl 1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-6,7-difluoro-8-(trimethylsilylethynyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (750 mg) was dissolved in tetrahydrofuran (6 ml). 1N Sodium hydroxide (2 ml) was added to this solution, and the mixture was stirred overnight at room temperature. After the reaction mixture was acidified with citric acid and then extracted with chloroform. An organic layer was dried over anhydrous magnesium sulfate, and the solvent was then distilled off under reduced pressure to obtain the title compound (240 mg) as a colorless powder.

Provenance & Evidence