Ammonia → HCID 69958639, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 1-(5-amino-2,4-difluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (200 mg) was dissolved in N,N-dimethylformamide (4 ml). 28% Aqueous ammonia (1 ml) was added to this solution, and the mixture was stirred overnight at 50° C. in a closed state. Additional 28% aqueous ammonia (2 ml) was added, and the mixture was stirred overnight in the same manner as described above. After the temperature of the reaction mixture was given back to room temperature, it was concentrated to two-thirds under reduced pressure. Red solids deposited were collected by filtration, washed with water and then dried to obtain the title compound (90 mg) as a reddish brown powder.

Provenance & Evidence