Potassium peroxymonosulphate → HCID 18362928, compound

HRID 369467Notes

Reaction equation

HRID 369467 reaction equation
[OH:1][CH2:2][CH2:3][S:4][C:5]1[N:6]([CH2:21][C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=[CH:24][CH:23]=2)[CH:7]=[C:8]2[C:13]=1[C:12](=[O:14])[N:11]([CH3:15])[C:10](=[O:16])[N:9]2[CH2:17][CH:18]([CH3:20])[CH3:19].S([O-])(O[O-])(=O)=[O:33].[K+].[K+].OOS([O-])=O.[K+]>CO.O>[OH:1][CH2:2][CH2:3][S:4]([C:5]1[N:6]([CH2:21][C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=[CH:24][CH:23]=2)[CH:7]=[C:8]2[C:13]=1[C:12](=[O:14])[N:11]([CH3:15])[C:10](=[O:16])[N:9]2[CH2:17][CH:18]([CH3:20])[CH3:19])=[O:33]

Participants

6

Reactant 3

HCID 10313463Potassium peroxymonosulphateHCID 232864205-(2-Hydroxyethyl)thio-3-methyl-1-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dioneHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 18362928HCID 18362928, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

To a stirred solution of 5-(2-hydroxyethyl)thio-3-methyl-1-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (100 mg) in methanol (20 ml) was added potassium peroxymonosulphate (commercially sold under the trade mark "OXONE") (300 mg) in water (10 ml). After stirring for 10 minutes the reaction mixture was diluted with water and extracted with ethyl acetate. The organic extracts were dried over magnesium sulphate and concentrated in vacuo. Chromatography on silica gel (ethyl acetate) gave the title compound (70 mg) as a white foam.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic extracts were dried over magnesium sulphate
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-d3c38a04cca34c3a93e06b370f212d60
Source dataset
uspto-grants-2000_10
Patent number
US06136974

Reaction notes

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