Formaldehyde → N-hydroxymethyl-4-chloro-3-methylpyrazole

HRID 369516Notes

Reaction equation

HRID 369516 reaction equation
[Cl:1][C:2]1[C:3]([CH3:7])=[N:4][NH:5][CH:6]=1.[CH2:8]=[O:9]>CO>[OH:9][CH2:8][N:5]1[CH:6]=[C:2]([Cl:1])[C:3]([CH3:7])=[N:4]1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 178434543HCID 178434543, compound

Product 1

HCID 11423670N-hydroxymethyl-4-chloro-3-methylpyrazoleYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

116 g (1.0 mol) of 4-chloro-3-methylpyrazole in 50 ml of methanol were dissolved in 100 g (1.0 mol) of formalin solution (30%) at room temperature. Water and methanol were then evaporated. The title compound remained as a white solid (yield 95%).

Workup

  1. customWater and methanol were then evaporated

Sources & evidence

ORD record
ord-178f2d7824dd43288d9ee3a99b1b2692
Source dataset
uspto-grants-2000_10
Patent number
US06139596

Reaction notes

Loading…