HCID 15067407, compound → 3-[4-(4-o-Cyanophenylpiperazino)butyl]-5-indolylurea, hydrochloride

HRID 36952Notes

Reaction equation

HRID 36952 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([NH:15][C:16]([NH2:18])=[O:17])[CH:13]=2)[NH:8][CH:7]=1.[Cl:19][CH2:20][CH2:21][N:22]([CH2:31][CH2:32]Cl)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[C:29]#[N:30]>CC(C)=O.O>[ClH:19].[C:29]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[N:22]1[CH2:31][CH2:32][N:1]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([NH:15][C:16]([NH2:18])=[O:17])[CH:13]=3)[NH:8][CH:7]=2)[CH2:20][CH2:21]1)#[N:30]

Participants

5

Reactant 2

HCID 15067407HCID 15067407, compoundHCID 19936501HCID 19936501, compound

Product 1

HCID 1317190073-[4-(4-o-Cyanophenylpiperazino)butyl]-5-indolylurea, hydrochloride

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

A mixture of 2.87 g of 3-(4-aminobutyl)-5-indolylurea [obtainable from 5-indolylurea via 3-(4-chlorobutyryl)-5-indolylurea, 3-(4-chlorobutyl) -5-indolylurea and 3-(4-phthalimidobutyl)-5-indolylurea] and one equivalent of N,N-bis(2-chloroethyl)-o-cyanoaniline ("C") in 40 ml of acetone and 40 ml of water is boiled for 24 hours and worked up in a conventional manner. 3-[4-(4-o-Cyanophenylpiperazino)butyl]-5-indolylurea, hydrochloride, m.p. 164°-166° is obtained.

Sources & evidence

ORD record
ord-d5f87e6c21ab4c81a787b5d021f8c965
Source dataset
uspto-grants-1995_05
Patent number
US05418237

Reaction notes

Loading…