HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Methyl-4-(trans-4-decenyloxy)-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Methyl 4-(octadecyloxy)benzoate | HCID 4189536 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Reactant | Dec-4-en-1-ol | HCID 5702619 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Methyl-4-(trans-4-decenyloxy)-benzoate | HCID 18521044 | 80% |
Reaction Steps
DEAD (641 mg, 3.68 mmol), phenol 34 (487 mg, 3.2 mmol), alcohol 26i (500 mg, 3.2 mmol), and TPP (966 mg, 3.68 -mmol) in 16 ml anhydrous ether were reacted according to the procedure for compound 35a. The crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5 to 90/10 (v/v, Hex/EtOAc). Evaporation of the solvent yielded 748 mg (80%) of colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06139771 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-9a90c8df748145509ba2b474a6a4236b |
| Source note | uspto-grants-2000_10 |