HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Methyl-4-(trans-5-decenyloxy)-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Methyl 4-(octadecyloxy)benzoate | HCID 4189536 | — |
| Reactant | 5-Decen-1-ol, (5E)- | HCID 5283292 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Methyl-4-(trans-5-decenyloxy)-benzoate | HCID 18521058 | 72% |
Reaction Steps
DEAD (256 mg, 1.47 mmol), phenol 34 (194 mg, 1.28 mmol), alcohol 26j (200 mg, 1.28 mmol), and TPP (386 mg, 1.47 mmol) in 13 ml anhydrous ether were reacted according to the procedure for compound 35a. The crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5 to 90/10 (v/v, Hex/EtOAc). Evaporation of the solvent yielded 266 mg (72%) of colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06139771 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-e52e70a0fad94010ab6d00296b042670 |
| Source note | uspto-grants-2000_10 |