HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → 3-[4-(4-phenylpiperazino)butyl]indole-5-carboxylic acid N-tert-butylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 3-[4-(4-Phenyl-piperazin-1-yl)-butyl]-1H-indole-5-carboxylic acid | HCID 11280358 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[4-(4-phenylpiperazino)butyl]indole-5-carboxylic acid N-tert-butylamide | HCID 54231088 | — |
Reaction Steps
A solution of 3.74 g of 3-[4-(4-phenylpiperazino)butyl]indole-5-carboxylic acid in 500 ml of DMF is treated with 1.01 g of N-methylmorpholine. A solution of one equivalent of tert-butylamine in 5 ml of DMF, 1.35 g of 1-hydroxybenzotriazole and a solution of 1.92 g of N-(3-dimethylaminopropyl-N'-ethylcarbodiimide hydrochloride in 20 ml of DMF are added with stirring. The mixture is stirred for 16 hours at 20° and the filtrate is evaporated. After working up in a conventional manner, 3-[4-(4-phenylpiperazino)butyl]indole-5-carboxylic acid N-tert-butylamide is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05418237 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-fb01b79ae5084866b09df52fd32128c1 |
| Source note | uspto-grants-1995_05 |