HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylene Glycol Monoethyl Ether → 3-[4-(4-m-Methoxyphenylpiperazino)butyl]indole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylene Glycol Monoethyl Ether | HCID 8146 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-[4-(4-m-Methoxyphenylpiperazino)butyl]-5-cyanoindole | HCID 19936482 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[4-(4-m-Methoxyphenylpiperazino)butyl]indole-5-carboxamide | HCID 19936456 | — |
Reaction Steps
A mixture of 30.6 g of 3-[4-(4-m-methoxyphenylpiperazino)butyl]-5-cyanoindole, 27.1 g of NaOH, 520 ml of water and 420 ml of diethylene glycol monoethyl ether is stirred for 3 hours at a bath temperature of 140°. It is cooled and worked up in a conventional manner, and 3-[4-(4-m-methoxyphenylpiperazino)butyl]indole-5-carboxamide is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05418237 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-f6566778685e4c7d97edb5d95ee8c66c |
| Source note | uspto-grants-1995_05 |