O-Xylene → 2-Cyano-4'-methylbiphenyl

Participants

Reaction Steps

15 g of 2-chlorobenzonitrile, 14.8 g of p-tolueneboronic acid and 28.9 g of sodium carbonate in 40 ml of glycol and 10 ml of water were heated to 120° C. At 80° C., 0.1 mol % of Pd(O)(TPPTS)3. 9H2O dissolved in 3 ml of H2O was added. The reaction mixture was held at 120° C. for 12 hours. After cooling, 50 ml of xylene were added and the organic phase was separated off. Distillation gave 10.5 g of 2-cyano-4'-methylbiphenyl (b.p. 140° C./mbar).

Provenance & Evidence