反应详情

温度

0 °C

Then, 16 g of 2-ethyl-6-methylphenol was dissolved in 200 ml of chloroform, to which 56.6 g of tetrabutylammonium tribromide was added in portions with stirring at 0° C. After stirring at room temperature for 1 hour, the solvent was distilled out under reduced pressure. The residue was dissolved in 300 ml of diethyl ether, washed with 10% hydrochloric acid and then water, dried over anhydrous magnesium sulfate and then concentrated to give a crude product. The crude product was subjected to silica gel chromatography, which afforded 23 g of 4-bromo-2-ethyl-6-methylphenol (yield, 92%).

1. additionwas added in portions
2. stirringAfter stirring at room temperature for 1 hour
3. distillationthe solvent was distilled out under reduced pressure
4. dissolutionThe residue was dissolved in 300 ml of diethyl ether
5. washwashed with 10% hydrochloric acid
6. dry with materialwater, dried over anhydrous magnesium sulfate
7. concentrationconcentrated
8. customto give a crude product