2,6-Lutidine → HCID 22457555, compound

Participants

Reaction Steps

3-Hydroxy-1-allyloxycarbonylpyrrolidine (0.34 g, 1.99 mmol) was dissolved in CH2Cl2 (40 mL). 2,6-Lutidine (0.7 mL, 6 mmol) was added at -20° C. followed by adding triflic anhydride (0.5 mL, 2.97 mmol). The mixture was kept at -20° C. for 40 min, diluted with CH2Cl2, washed with water, 0.1 N HCl aqueous solution, water and brine, dried over Na2SO4 and concentrated to give the trifalte (0.63 g). The triflate (0.43 g, 1.42 mmol) was reacted with 1,4-diazabicyclo[2.2.2]octane (0.15 g, 1.34 mmol) in CH3CN overnight. The solvent was removed and the residue was dried under vacuum to give the product (0.42 g).

Provenance & Evidence