関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chloroacetonitrile | HCID 7856 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Eltoprazine | HCID 65853 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | HCID 10611289 | HCID 10611289 | — |
反応手順
A solution of 1-(1,4-benzodioxan-5-yl)piperazin (11 g) and triethylamine (7 ml) in N-methyl-2-pyrrolidinone was treated dropwise with chloroacetonitrile (4.5 g). After stirring for 2 h at 100° C. the mixture was poured onto ice and extracted with ethyl acetate. The organic phase was washed with water, dried over magnesium sulfate, filtered, and concentrated in vacuo. The product, 1-(1,4-benzodioxan-5-yl)-4-cyanomethylpiperazine, was obtained as an oil (17.4 g) which was sufficiently pure for use in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06140331 |
|---|
| 出典データセット | uspto-grants-2000_10 |
|---|
| ORD ID | ord-af384c9025af431e988eb164518e50de |
|---|
| 出典メモ | uspto-grants-2000_10 |
|---|
