HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 20706039, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Isobutylene | HCID 8255 | — |
| Reactant | HCID 20706028 | HCID 20706028 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 20706039 | HCID 20706039 | 81% |
Reaction Steps
According to example 54, 0.65 g of 3-cyclobutyl-L-phenylalanine·HCl was treated with 25 mL of isobutylene in 25 mL of 1,4-dioxane in the presence of 0.5 mL of conc. H2SO4. Work-up in the usual manner followed by acidification of the free amine with ethereal HCl afforded 0.64 g (81%) of tert-butyl 3-cyclobutyl-L-phenylalaninate·HCl as a white powder, m.p. 173-174° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06140100 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-bcc2a6cb7c2a4196a242b3dd5368ef48 |
| Source note | uspto-grants-2000_10 |