Benzoyl Peroxide → 6-(Bromomethyl)-2-methyl-4(1H)-quinazolinone

Participants

Reaction Steps

According to example 4, 1.00 g of 3,4-dihydro-2,6-dimethyl-4-oxoquinazoline (Sen, A. B.; Gupta, J. K. J. Indian Chem. Soc., 1962, 31, 369) was subjected to bromination using 1.05 g of N-bromosuccinimide (Aldrich) and 0.17 g of benzoyl peroxide in 50 mL of 1,2-dichloro-ethane for 30 min to afford 0.95 g (64%) of 6-bromomethyl-3,4-dihydro-2-methyl-4-oxoquinazoline as a tan solid.

Provenance & Evidence