3-Chloroaniline → HCID 23282760, compound

Participants

Reaction Steps

6.6 g (25.4 mmol) of 4-chloro-6-(2-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidine and 5.34 ml (50.8 mmol) of 3-chloro-aniline in 100 ml of n-butanol are heated at boiling for 1.5 hours. The reaction mixture is cooled, then filtered and washed with diethyl ether and hexane. Flash chromatography (SiO2 ; applied dry; hexane/ethyl acetate [2:1] ethanol/acetone [1:1]) yields the title compound; m.p. 221-222° C.; TLC-Rf =0.3 (hexane/ethyl acetate [1:1]); FAB-MS: (M+H)+ =351.

Provenance & Evidence