Phosphorus oxychloride → 4-chloro-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Participants

Reaction Steps

With the exclusion of moisture, 1.795 g (8.5 mmol) of 6-phenyl-7H-pyrrolo[2,3-d]-pyrimidin-4-ol and 27 ml of phosphorus oxychloride are heated at boiling for 3 hours. Pouring the reaction mixture into ice-water, filtering and washing with hot isopropanol and hexane yield the title compound; FAB-MS: (M+H)+ =230.

Provenance & Evidence