HCID 23282592, compound → HCID 23282594, compound

HRID 369881Notes

Reaction equation

HRID 369881 reaction equation
[CH3:1][CH:2]1[N:7]([CH3:8])[CH2:6][CH2:5][N:4]([CH:9]2[CH2:14][CH2:13][N:12](CC3C=CC=CC=3)[CH2:11][CH2:10]2)[CH2:3]1>C(O)C.[OH-].[Pd+2].[OH-].[C]>[CH3:1][CH:2]1[N:7]([CH3:8])[CH2:6][CH2:5][N:4]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH2:3]1

Participants

4

Reactant 1

HCID 23282592HCID 23282592, compound

Product 1

HCID 23282594HCID 23282594, compoundYield 57.2%

Reagents, catalysts & solvents 2

HCID 178502593HCID 178502593, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of 4-(3,4-dimethyl-1-piperazinyl)-1-benzylpiperidine (4.2 g) in ethanol (50 ml) is added 20% palladium hydroxide-carbon (0.4 g), and the mixture is subjected to catalytic hydrogenation at 50° C. under atmospheric pressure. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure. The residue is evaporated to give 4-(3,4-dimethyl-1-piperazinyl)piperidine (1.65 g).

Workup

  1. customis subjected to catalytic hydrogenation at 50° C. under atmospheric pressure
  2. customThe catalyst is removed by filtration
  3. concentrationthe filtrate is concentrated under reduced pressure
  4. customThe residue is evaporated

Sources & evidence

ORD record
ord-8ab3fcdc4262446a958e9ff38127cb79
Source dataset
uspto-grants-2000_10
Patent number
US06140330

Reaction notes

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