1-(2-Hydroxyethyl)piperazine → 4-Benzyl-2-[4-(2-hydroxyethyl)-1-piperazinyl]methylmorpholine

HRID 369885Notes

Reaction equation

HRID 369885 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14]Cl)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:16][CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][N:22]2[CH2:23][CH2:24][N:19]([CH2:18][CH2:17][OH:16])[CH2:20][CH2:21]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 28015624-Benzyl-2-(chloromethyl)morpholine

Product 1

HCID 232826134-Benzyl-2-[4-(2-hydroxyethyl)-1-piperazinyl]methylmorpholine

Conditions

Temperature
130 °C

Procedure

4-Benzyl-2-chloromethylmorpholine (15 g) and 4-(2-hydroxyethyl)piperazine (25 ml) are mixed, and the mixture is heated with stirring at 130° C. for five hours. After the reaction is complete, the mixture is extracted with chloroform, and the extract is dried over magnesium sulfate. The residue thus obtained is concentrated under reduced pressure to give 4-benzyl-2-[4-(2-hydroxyethyl)-1-piperazinyl]methylmorpholine (16 g).

Workup

  1. temperaturethe mixture is heated
  2. extractionthe mixture is extracted with chloroform
  3. dry with materialthe extract is dried over magnesium sulfate
  4. customThe residue thus obtained
  5. concentrationis concentrated under reduced pressure

Sources & evidence

ORD record
ord-b7153b6805704f9cb07800b32af7ae84
Source dataset
uspto-grants-2000_10
Patent number
US06140330

Reaction notes

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