反应详情

温度

130 °C

4-Benzyl-2-chloromethylmorpholine (15 g) and 4-(2-hydroxyethyl)piperazine (25 ml) are mixed, and the mixture is heated with stirring at 130° C. for five hours. After the reaction is complete, the mixture is extracted with chloroform, and the extract is dried over magnesium sulfate. The residue thus obtained is concentrated under reduced pressure to give 4-benzyl-2-[4-(2-hydroxyethyl)-1-piperazinyl]methylmorpholine (16 g).

1. temperaturethe mixture is heated
2. extractionthe mixture is extracted with chloroform
3. dry with materialthe extract is dried over magnesium sulfate
4. customThe residue thus obtained
5. concentrationis concentrated under reduced pressure