反应详情

In 2 ml of 10% HCl-methanol, 84 mg of 4-t-butoxycarbonylamino-1-{(2R)-2-((1R)-3, 3-difluorocyclopentyl)-2-hydroxy-2-phenylacetyl}piperidine was dissolved, and stirred for 3 hours at room temperature. The solvent was distilled off under reduced pressure, and 60 mg of the title compound was obtained as a colorless solid by recrystallizing the resulting residue from ethyl acetate/hexane.

1. distillationThe solvent was distilled off under reduced pressure