HCID 54251644, compound → HCID 44308746, compound

Participants

Reaction Steps

To a solution of 568 mg of 4-benzyloxycarbonylamino-1-{(2R)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylacetyl}-4-methylpiperidine in a mixture of 10 ml of methanol and 5 ml of ethyl acetate, 200 mg of 10% palladium-carbon catalyst was added, followed by stirring for 18 hours under a hydrogen atmosphere. After filtering the catalyst off, the solvent was distilled off under reduced pressure, and the resulting residue was dissolved in 1M hydrochloric acid and washed with diethyl ether. After basifying with 4N sodium hydroxide, the aqueous layer was extracted with chloroform, and dried over anhydrous magnesium sulfate to give 320 mg of the title compound as a colorless oily substance.

Provenance & Evidence