HCID 15407445, compound → HCID 15407446, compound

HRID 369933Notes

Reaction equation

HRID 369933 reaction equation
[CH3:1][CH:2]1[CH2:11][C:10]2[C:5](=[CH:6][C:7]([N+:12]([O-])=O)=[CH:8][CH:9]=2)[CH2:4][NH:3]1>CO>[CH3:1][CH:2]1[CH2:11][C:10]2[C:5](=[CH:6][C:7]([NH2:12])=[CH:8][CH:9]=2)[CH2:4][NH:3]1

Participants

3

Reactant 1

HCID 15407445HCID 15407445, compound

Product 1

HCID 15407446HCID 15407446, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-Methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline (3.0 g, 13.1 mmol) was dissolved in MeOH (100 ml) and hydrogenated at 50 psi in the presence of a catalytic quantity of 10% Pd--C. After 1 h the mixture was filtered through glass and evaporated to an oil which was used immediately in the next reaction.

Workup

  1. filtrationAfter 1 h the mixture was filtered through glass
  2. customevaporated to an oil which
  3. customwas used immediately in the next reaction

Sources & evidence

ORD record
ord-f747b1dd2dec4356b61b094765702491
Source dataset
uspto-grants-2000_10
Patent number
US06140322

Reaction notes

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