(E)-[2-n-Butyl-1-{(2-methoxyphenyl)methyl}1H-imidazol-5-yl]-2(2-thienyl)methyl-2-propenoic Acid → HCID 14952904, compound

HRID 36994Notes

Reaction equation

HRID 36994 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[O:28]C)[C:7](/[CH:10]=[C:11](\[CH2:15][C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)/[C:12]([OH:14])=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]>C(Cl)Cl>[CH2:1]([C:5]1[N:6]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[OH:28])[C:7](/[CH:10]=[C:11](\[CH2:15][C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)/[C:12]([OH:14])=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 14952911(E)-[2-n-Butyl-1-{(2-methoxyphenyl)methyl}1H-imidazol-5-yl]-2(2-thienyl)methyl-2-propenoic Acid

Product 1

HCID 14952904HCID 14952904, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from the 2-methoxy compound prepared in Example 64 using boron tribromide in methylene chloride; 181°-183° C.

Workup

  1. custom181°-183° C.

Sources & evidence

ORD record
ord-effccef9bbcd4dde8eb0c592c0791256
Source dataset
uspto-grants-1995_05
Patent number
US05418250

Reaction notes

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