HCID 21584307, compound → HCID 21584272, compound

HRID 369946Notes

Reaction equation

HRID 369946 reaction equation
[ClH:1].[CH3:2][N:3]1[CH:12]([CH3:13])[CH2:11][C:10]2[C:5](=[CH:6][C:7]([N+:14]([O-])=O)=[CH:8][CH:9]=2)[CH2:4]1>CO>[ClH:1].[CH3:2][N:3]1[CH:12]([CH3:13])[CH2:11][C:10]2[C:5](=[CH:6][C:7]([NH2:14])=[CH:8][CH:9]=2)[CH2:4]1

Participants

3

Reactant 1

HCID 21584307HCID 21584307, compound

Product 1

HCID 21584272HCID 21584272, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 2,3-dimethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride (2.0 g, 8.24 mmol) in methanol (100 ml) was added a catalytic amount of 10% Pd--C. The mixture was hydrogenated at 50 psi for 1 h, filtered, and concentrated to a solid which was used immediately in the next reaction (1.6 g, 92%), m.p. 215-217° C.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated to a solid which
  3. customwas used immediately in the next reaction (1.6 g, 92%), m.p. 215-217° C.

Sources & evidence

ORD record
ord-24df93fe23b0400a8b4378c273c33ee4
Source dataset
uspto-grants-2000_10
Patent number
US06140322

Reaction notes

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