HCID 70127292, compound → HCID 70127009, compound

HRID 369949Notes

Reaction equation

HRID 369949 reaction equation
[ClH:1].[CH3:2][N:3]1[C:9]2[CH:10]=[CH:11][C:12]([N+:14]([O-])=O)=[CH:13][C:8]=2[CH2:7][N:6]2[CH2:17][CH2:18][CH2:19][CH:5]2[CH2:4]1>CO>[ClH:1].[NH2:14][C:12]1[CH:11]=[CH:10][C:9]2[N:3]([CH3:2])[CH2:4][CH:5]3[CH2:19][CH2:18][CH2:17][N:6]3[CH2:7][C:8]=2[CH:13]=1

Participants

3

Reactant 1

HCID 70127292HCID 70127292, compound

Product 1

HCID 70127009HCID 70127009, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 10-methyl-7-nitro-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazapine hydrochloride (2.6 g, 9.16 mmol) in methanol (100 ml) was added a catalytic amount of 10% Pd--C. The mixture was hydrogenated at 50 psi for 1 h, filtered, and concentrated to an oil which was used immediately in the next reaction.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated to an oil which
  3. customwas used immediately in the next reaction

Sources & evidence

ORD record
ord-71f5b903326e47349aede49c455752e9
Source dataset
uspto-grants-2000_10
Patent number
US06140322

Reaction notes

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