Methyl 3-benzyl-3-(2-thienyl)propanoate → (E)-3-[2-n-Butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-[2-phenyl-1-(2-thienyl)ethyl]-2-propenoic Acid

Participants

Role	Name	HCID	Charge
Reactant	Methyl 3-benzyl-3-(2-thienyl)propanoate	HCID 10038247	—
Reactant	1-(2-chlorophenyl)methyl-5-carboxymethyl-2-propylthio-1H-imidazole	HCID 19351554	—
Reactant	HCID 19936813	HCID 19936813	—
Reactant	(E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(4-pyridyl)-methyl-2-propenoic acid	HCID 86746549	—
Product	(E)-3-[2-n-Butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-[2-phenyl-1-(2-thienyl)ethyl]-2-propenoic Acid	HCID 10074878	—

Reaction Steps

The title compound was prepared using the procedure of Example 1 (i, ii, iii, iv [Method B]) replacing methyl 3-(2-thienyl)propanoate with methyl 3-benzyl-3-(2-thienyl)propanoate [prepared following the procedure described in Tetra. 44 (7) 2055 (1988)]; mp 200°-202° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05418250
Source dataset	uspto-grants-1995_05
ORD ID	ord-8240ab9cf4f1465f88c8d996297978f2
Source note	uspto-grants-1995_05