HCID 21584276, compound → HCID 21584290, compound

HRID 369954Notes

Reaction equation

HRID 369954 reaction equation
[ClH:1].[CH2:2]([CH:4]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([N+:14]([O-])=O)=[CH:10][CH:11]=2)[CH2:6][N:5]1[CH3:17])[CH3:3].Cl.C(O)(C)C>CO>[ClH:1].[ClH:1].[NH2:14][C:9]1[CH:8]=[C:7]2[C:12]([CH2:13][CH:4]([CH2:2][CH3:3])[N:5]([CH3:17])[CH2:6]2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 21584276HCID 21584276, compoundHCID 21912024Isopropanol hydrochloride

Product 1

HCID 21584290HCID 21584290, compoundYield 192.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a pressure bottle charged with 3-ethyl-2-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride (3.6 g, 17 mmols) dissolved in methanol (100 ml) and saturated isopropanol-HCl (20 ml) was added 10% Pd--C (250 mg), and the reaction was hydrogenated for 1 h. The catalyst was removed by filtration and the solvent evaporated to give the title compound (4.3 g).

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-61f1710a92c146c08d8372d87e84713f
Source dataset
uspto-grants-2000_10
Patent number
US06140322

Reaction notes

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