HCID 21584334, compound → HCID 21584263, compound

HRID 369962Notes

Reaction equation

HRID 369962 reaction equation
[ClH:1].[N+:2]([C:5]1[CH:6]=[CH:7][C:8]2[O:14][CH2:13][CH:12]3[CH2:15][CH2:16][CH2:17][CH2:18][N:11]3[CH2:10][C:9]=2[CH:19]=1)([O-])=O>CO.[Pd]>[ClH:1].[NH2:2][C:5]1[CH:6]=[CH:7][C:8]2[O:14][CH2:13][CH:12]3[CH2:15][CH2:16][CH2:17][CH2:18][N:11]3[CH2:10][C:9]=2[CH:19]=1

Participants

4

Reactant 1

HCID 21584334HCID 21584334, compound

Product 1

HCID 21584263HCID 21584263, compoundYield 103.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-Nitro-6,6a,7,8,9,10-hexahydro-12H-pyrido[2,1-c][1,4]benzoxazepine hydrochloride (2.46 g) dissolved in methanol (50 ml) was treated with 10% Pd-C (0.25 g), and hydrogenated on a Parr Hydrogenator for one hour, filtered and evaporated to yield a tacky solid (2.28 g).

Workup

  1. filtrationfiltered
  2. customevaporated

Sources & evidence

ORD record
ord-77c830ba9fc44d42be6bb543f1ae9a5e
Source dataset
uspto-grants-2000_10
Patent number
US06140322

Reaction notes

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