HCID 70128601, compound → HCID 70126959, compound

HRID 369964Notes

Reaction equation

HRID 369964 reaction equation
[ClH:1].[N+:2]([C:5]1[CH:6]=[CH:7][C:8]2[O:14][CH:13]([CH2:15][CH3:16])[CH2:12][NH:11][CH2:10][C:9]=2[CH:17]=1)([O-])=O>CO.[Pd]>[ClH:1].[NH2:2][C:5]1[CH:6]=[CH:7][C:8]2[O:14][CH:13]([CH2:15][CH3:16])[CH2:12][NH:11][CH2:10][C:9]=2[CH:17]=1

Participants

4

Reactant 1

HCID 70128601HCID 70128601, compound

Product 1

HCID 70126959HCID 70126959, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 23938PalladiumSolvent

Procedure

7-Nitro-2-ethyl-2,3,4,5-tetrahydro-1,4-benzoxazapine hydrochloride (3.4 g, 13.1 mmol) was dissolved in methanol (100 ml) and hydrogenated at 50 psi in the presence of a catalytic quantity of 10% Pd-C. After 1 h the mixture was filtered through glass and evaporated to an oil which was used immediately in the next reaction.

Workup

  1. filtrationAfter 1 h the mixture was filtered through glass
  2. customevaporated to an oil which
  3. customwas used immediately in the next reaction

Sources & evidence

ORD record
ord-fbc5c12c8659482fabda85859dd30805
Source dataset
uspto-grants-2000_10
Patent number
US06140322

Reaction notes

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