HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (E)-3-[2-n-Butyl-1-{(4-carbomethoxyphenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Methyl 4-[(2-butyl-5-formyl-1H-imidazol-1-YL)methyl]benzoate | HCID 10334966 | — |
| Reactant | t-Butyl 3-(2-thienyl)-propanoate | HCID 11310395 | — |
| Reactant | 2-n-Butyl-1-(4-carboethoxy-2-chlorobenzyl)imidazole-5-aldehyde | HCID 19936789 | — |
| Reactant | (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(4-pyridyl)-methyl-2-propenoic acid | HCID 86746549 | — |
| Product | (E)-3-[2-n-Butyl-1-{(4-carbomethoxyphenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid | HCID 14952889 | — |
Reaction Steps
The title compound was prepared using 2-n-butyl-1-[(4carbomethoxyphenyl)methyl]imidazole-5-aldehyde (prepared by the method described for the preparation of 2-n-butyl-1-[(4-carboethoxy-2-chlorophenyl)methyl]imidazole-5-aldehyde in Example 42) and t-butyl 3-(2-thienyl)-propanoate by the procedure of Example 1 (iv, Method B), except, instead of basic hydrolysis, trifluoroacetic acid hydrolysis of the t-butyl ester was employed; mp 217°-220° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05418250 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-c4c8546c7774425b944f4c19b9eb3017 |
| Source note | uspto-grants-1995_05 |