HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1-Methyl-7-nitro-3,4-dihydroisoquinoline | HCID 10932228 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride | HCID 21584310 | — |
Reaction Steps
To a solution of 1-methyl-7-nitro-3,4-dihydroisoquinoline (397 g, 20.9 mmol) in methanol (80 ml) was added sodium borohydride (0.87 g, 23.0 mmol) portionwise. The mixture was stirred for 30 min., acidified with 6N HCl, the solvent was evaporated and the solid was stirred in isopropanol, collected and washed with ether: 5.33 g (>100%); MS (M+H)+ 193.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06140322 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-210841e8a536430f944b649ae733f9ae |
| Source note | uspto-grants-2000_10 |