1-Methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride → 1-Methyl-1,2,3,4-tetrahydroisoquinolin-7-amine hydrochloride

Participants

Reaction Steps

A suspension of 1-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride (2.0 g, 8.75 mmol) in ethanol (100 ml) and a catalytic quantity of 10% Pd-C was hydrogenated until no more hydrogen was taken up. The catalyst was filtered off, the solvent was concentrated to a small volume, ether was added and the precipitated solid was collected and dried: 1.39 g (78%), MS (M+H)+ 163.

Provenance & Evidence