Diethyl Ether → HCID 23282954, compound

HRID 370273Notes

Reaction equation

HRID 370273 reaction equation
Cl.CO.C(O[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH:19]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:14][CH2:13]1)=[O:10])(C)(C)C.[CH2:27]([O:29][CH2:30][CH3:31])[CH3:28]>>[CH:19]1([CH2:18][N:15]2[CH2:14][CH2:13][CH:12]([NH:11][C:9]([C:13]3[CH:12]=[CH:17][CH:28]=[C:27]4[C:14]=3[NH:15][C:31]3[CH:21]=[CH:20][CH:19]=[CH:18][C:30]=3[O:29]4)=[O:10])[CH2:17][CH2:16]2)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 10520047HCID 10520047, compoundHCID 21893726Hydrochloride methanol

Product 1

HCID 23282954HCID 23282954, compound

Procedure

15 ml of 10% HCl-methanol solution and 15 ml of diethyl ether were added to 1.66 g of 4-t-butoxycarbonylamino-1-cyclooctylmethylpiperidine, followed by stirring for 18 hours. The solvent was distilled off under reduced pressure, the obtained residue was washed with diethyl ether, and 1.44 g of the title compound as a white solid was obtained.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. washthe obtained residue was washed with diethyl ether

Sources & evidence

ORD record
ord-cb9700f158a2430fb1bf5fc362830fb3
Source dataset
uspto-grants-2000_10
Patent number
US06140338

Reaction notes

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