HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3,5,6-Tetrafluorophenyl 5-(9-Acridinyl)pentanoate → 1-[5-(9-Acridinyl)-1-oxopentyl]-5-hydroxymethyl-(3R-trans)-3-pyrrolidinol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3,5,6-Tetrafluorophenyl 5-(9-Acridinyl)pentanoate | HCID 19934285 | — |
| Reactant | 1-[5-(9-Acridinyl)-1-oxopentyl]-5-hydroxymethyl-(3R-trans)-3-pyrrolidinol | HCID 22853587 | — |
| Product | Acridine | HCID 9215 | — |
| Product | 1-[5-(9-Acridinyl)-1-oxopentyl]-5-hydroxymethyl-(3R-trans)-3-pyrrolidinol | HCID 22853587 | 92% |
Reaction Steps
A procedure similar to that described in Example XXIV was used for the preparation of 21. 1.28 g (3.00 mmol) of acridine TFP ester 20 gave 1.04 g (92% yield) of 21 as a pale yellow solid foam:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05419966 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-11b09e838dbb4d5b8db53e3e9d14a692 |
| Source note | uspto-grants-1995_05 |