HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 370342Generated: October 27, 2026
Dimethylformamide → 4-(Pentafluorosulfanyl)benzoyl chloride
https://huagongshe.com/reaction/370342
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-(Pentafluoro-lambda6-sulfanyl)benzoic acid | HCID 2779210 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 4-(Pentafluorosulfanyl)benzoyl chloride | HCID 2779215 | 100.6% |
Reaction Steps
Oxalyl chloride (1.53 g) was added to a stirred solution of 4-pentafluorosulphanyl- benzoic acid (0.99 g) in dichloroethane. A solution of N,N-dimethylformamide in dichloromethane (3 ml of a solution prepared by the addition of 2 drops of N,N-dimethylformamide to 10 ml of dichloromethane) was added. After 15 minutes the solution was heated for a further 15 minutes at 45° C., and evaporated to dryness to give 4-pentafluorosulphanylbenzoyl chloride as an orange oil (1.07 g). This was used directly in the subsequent reaction stage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06140528 |
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| Source dataset | uspto-grants-2000_10 |
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| ORD ID | ord-9185e434777f4953a124191c2774e521 |
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| Source note | uspto-grants-2000_10 |
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