Chloroacetone → HCID 20276033, compound

Participants

Reaction Steps

A mixture consisting of 24.0 g of o-isopropylphenol, 17.0 g of chloroacetone, 30 g of potassium carbonate, 1.0 g of potassium iodide and 150 ml of acetone was heated at reflux with stirring for 6 hr. The reaction mixture was concentrated under reduced pressure; the condensate was extracted with ethyl acetate; the ethyl acetate layer was washed consecutively with 5% aqueous solution of sodium hydroxide, water and saturated saline, and thereafter dried with anhydrous sodium sulfate. The solvent was thereafter distilled off under reduced pressure and yielded 38 g of 2-isopropylphenoxyacetone.

Provenance & Evidence